Candidate of Philology, Head of the Department of Rare Books and Manuscripts of the State Public Scientific Technical Library of the Siberian Branch of the Russian Academy of Sciences, specialist in the history of Old Russian literature, textual criticism and archaeography, organizer and participant of integrated folklore and archeographic expeditions to Siberia and the Far East. The main areas of scientific activity of A. Yu. Borodikhin are archaeography and source studies, book history, preservation and use of literary monuments and monuments of art, Old Believer literary culture, textological study of Russian chronicles and historical texts. Author of monographic works on the fate of Old Russian literary culture in modern Siberia, he has published more than 100 reserch papers, in Russia and abroad. Lecturer at the Humanities Institute of Novosibirsk State University (courses "Palaeography and Textology", "Old Russian Literature", special courses on modern techniques for publishing literary monuments), permanent supervisor of folklore and archaeographic internship expeditions for philology students of the NSU.
He is a member of the editorial board of the serial collection of scientific papers Knizhnaya starina ("Book Antiquity"), a member of the editorial board of the scientific journal Bibliosfera ("Bibliosphere"), the scientific editor of catalogues and monographic works published by the State Public Scientific Technical Library of the Siberian Branch of the Russian Academy of Sciences in the book series Materialy Svodnogo kataloga rukopisei, staropechatnykh i redkikh knig v sobraniiakh Sibiri i Dal’nego Vostoka ("Materials for the Comprehensive Catalog of Manuscripts, Early Printed and Rare Books in Collections of Siberia and the Far East"), Kniga i literatura ("Book and Literature").
Expert on cultural property of the Ministry of Culture of the Russian Federation, member of the standing committee of the section on valuable manuscripts and rare books of the Russian Library Association, awarded with the title "Honored Worker of Culture of the Russian Federation".